產品描述

塔望科技開發的小動物頭外置體積描記系統（Head-Out Plethysmography），采用特殊設計，使小動物的頸部與身體隔開，口鼻暴露在外面，實時測定容納身體的腔室內氣體容積與壓力的變化。Glaab等對哮喘小鼠使用mACh激發后，取呼氣中段流量(EF50 )下降55％時的mACh量( EF50)為指標來表示支氣管反應的敏感性，研究證明，EF50和RL及CL有較好的相關性，可較好地反映呼吸系統的機械動力學改變。

產品特點

小動物頭外置體積描記系統采用頭外置式體積描記系統測量過程中，動物保持清醒狀態，不需要麻醉，避免了創傷性氣管切開術及麻醉的影響，使實驗過程簡便快捷，并適合長期跟蹤研究。

另外系統可擴展連接霧化給藥器，對動物進行霧化給藥，建立咳嗽、哮喘等呼吸道疾病模型，系統可檢測和記錄激發過程中呼吸常規指標和氣道高反應的變化，用以評價支氣管收縮情況。

• 不需要做手術，操作簡單。

• 動物處于清醒狀態，結果不受麻醉和手術影響。

• 可以實現在同一只動物上做長期跟蹤實驗。

• 配備氣溶膠霧化模塊 。（可根據實驗要求選配）

• 可聯合同步測量其它信號，如體溫、血壓、心電信號等。

小動物頭外置體積描記系統可連接口鼻暴露系統，實時在線監測動物肺功能指標的變化

檢測參數

小動物頭外置體積描記系統

Ti：吸氣時間（s）

Te：呼氣時間（s）

PIF：最大吸氣流速（ml/s）

PEF：最大呼氣流速（ml/s）

Volbal：吸氣時間/呼氣時間

F：呼吸頻率（次/min）

Vt：潮氣量（ml）

Mv：分鐘通氣量（ml）

AV：累積體積（ml）

EF50：呼出50%氣量時對應的呼氣流速（ml/s）

EIP：吸氣末暫停時間

EEP：呼氣末暫停時間

TR：松弛時間

PenH：增強呼氣間歇（enhanced pause）

Rpef：相對時間

小動物頭外置體積描記系統應用領域

哮喘Asthma

肺纖維化Lung Fibrosis

慢性阻塞性肺病COPD

急性呼吸系統疾病Acute Respiratory Disorders

模型開發Model Development

安全評估 Safety Assessment

毒理學Toxicology

小動物頭外置體積描記系統型號選擇

小動物頭外置體積描記系統用戶名單

小動物頭外置體積描記系統相關文獻

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